![]() ![]() It comprising a total area of 65.99 sq mi (170.92 km2), with an estimated population of 319,294 in 2019, 11th largest city in the Midwest, 2nd largest city in Missouri and 65th largest city in the United States. It lies on the west bank of the Mississippi River opposite East St. ![]() Louis is the 2nd largest city in eastern-central portion of Missouri, United States. ![]()
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